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doi: 10.1038/nature12034 136 LiYYunKMuR

Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins

The final search query was "(disease terms) AND (mechanism/target terms OR intervention terms)", ensuring precise retrieval of studies focusing on "the association between SLE and gut microbiota/metabolism"

Most lines of treatment aim to reduce the symptoms of this condition and help people manage their pain to maintain a normal daily life

The clinical team initiates buprenorphine/naloxone at appropriate COWS thresholds to minimize withdrawal intensity and address cravings before early discharge risk rises